A Transplacental Carcinogenicity Bioassay in CD-1 Mice with Zidovudine
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منابع مشابه
A transplacental carcinogenicity bioassay in CD-1 mice with zidovudine.
In oral carcinogenicity bioassays, zidovudine (ZDV) induced vaginal epithelial cell tumors in mice given 30 or 40 mg/kg/day and rats given 300 mg/kg/day. To determine if lifetime exposure to ZDV, beginning perinatally, would alter this pattern of carcinogenicity, two groups of 60 pregnant CD-1 mice were given 20 or 40 mg/kg/day of ZDV in 0.5% methyl cellulose from Gestation Day 10 through Lacta...
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Zidovudine (ZDV), an antiviral drug active in the treatment of acquired immunodeficiency syndrome (recommended human dose, 100 mg every 4 hr while awake), was evaluated for mutagenic and carcinogenic potential in a battery of short-term in vitro and in vivo assays and in lifetime studies in mice and rats. In L5178Y mouse lymphoma cells (tk+/- locus), a weak positive result was obtained only at ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1997
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/38.2.195